A frameshift mutation is a particular type of mutation that involves either insertion or deletion of extra bases of DNA Now, what's important here is the number three The number of bases that are either added or subtracted can't be divisible by three And that's important because the cell reads a gene in groups of three basesINSERTION One or more extra nucleotides are inserted or added into the replicating DNA, often resulting in frameshift As a result, the protein made by the gene may not function properly DELETION Changes the number of DNA bases by removing a piece of DNAPoint mutation Insertion One or more extra nucleotides are inserted into replicating DNA, often resulting in a frameshift One form of betathalassemia Deletion One or more nucleotides is "skipped" during replication or otherwise excised, often resulting in a frameshift Cystic fibrosis Chromosomal mutation Inversion One region of a chromosome is flipped and reinserted
Chapter 12 Dna Damage And Repair Chemistry
